I liked Pokemon up to the end of Master Quest (The third part of the Johto saga). After Misty left the show seemed to go down hill, with episode after episode of Team Rocket turning up, trying to capture Pikachu and some other star if the episode and failing.
I've only got and read the Red, Blue, Green series of the Manga. I'd much rather see them made into an anime than what we've been given.
The game are still awesome.
I think after the big step down that was Ruby, Sapphire and Emerald, it's good to see them back on track with Diamond, Pearl and Platinum. I really can't wait for Heart Gold and Soul Silver. The remakes of the best Pokemon games made.